Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione depletion biomarkers ophthalmic acid and 5 oxoproline in humans and rats Integrative Biology (RSC Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Good ol' paracetamol: 'But an overconsumption takes its toll' Journal of Anaesthesia Practice
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glutathione depletion paracetamol Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential